I Nyoman Hariyasa Sanjaya
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Udayana, Prof. dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia
Wiku Andonotopo
Maternal-Fetal Medicine Division, Women's Health Center, Department of Obstetrics and Gynecology, Ekahospital BSD City, Serpong, Tangerang, Banten, Indonesia
Muhammad Adrianes Bachnas
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Medical Faculty, Universitas Sebelas Maret, Dr. Moewardi Hospital, Solo, Surakarta, Indonesia
Julian Dewantiningrum
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Medical Faculty, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia
Mochammad Besari Adi Pramono
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Medical Faculty, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia
Ryan Saktika Mulyana
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Udayana, Prof. dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia
Evert Solomon Pangkahila
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Udayana, Prof. dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia
Muhammad Ilham Aldika Akbar
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia
Theresia Monica Rahardjo
Faculty of Medicine, Universitas Kristen Maranatha, Bandung, West Java, Indonesia
Aloysius Suryawan
Faculty of Medicine, Universitas Kristen Maranatha, Bandung, West Java, Indonesia
Bambang Rahardjo
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia
Cut Meurah Yeni
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Syiah Kuala, Dr. Zainoel Abidin General Hospital, Aceh, Indonesia
Dudy Aldiansyah
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik General Hospital, Medan, Indonesia
Nuswil Bernolian
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sriwijaya, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Anak Agung Gede Putra Wiradnyana
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Udayana, Prof. dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia.
Sri Sulistyowati
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Medical Faculty, Universitas Sebelas Maret, Dr. Moewardi Hospital, Solo, Surakarta, Indonesia
Milan Stanojevic
Medical University of Warsaw, Department of Neonatology and Rare Diseases, Poland
Asim Kurjak
Department of Obstetrics and Gynecology, Medical School, University of Zagreb, Zagreb, Croatia
Keywords
Perinatal ethnopharmacology, Indonesian medicinal plants, Pregnancy and postpartum care, Lactation and galactagogues, Herbal medicine, Maternal health
Abstract
Background: The perinatal period involves significant physiological and metabolic transitions, particularly concerning hypertensive disorders, preeclampsia, hemorrhage, lactation challenges, and oxidative stress. Although pharmacological therapies are available, their safety and accessibility remain inconsistent, especially in resource-limited settings. Indonesia’s extensive biodiversity and deep-rooted ethnomedicinal traditions offer promising yet underutilized botanical alternatives. This study aimed to review the efficacy of Indonesian medicinal plants used in pregnancy, postpartum, and lactation.
Methods: This systematic review investigates ten Indonesian medicinal plants traditionally used during pregnancy, postpartum recovery, and lactation: Sauropus androgynus, Curcuma longa, Moringa oleifera, Nigella sativa, Centella asiatica, Orthosiphon aristatus, Syzygium polyanthum, Andrographis paniculata, Solanum nigrum, and Zingiber officinale. Literature from 2000 to 2025 was reviewed using PRISMA guidelines across global and regional databases. Phytochemical composition, mechanisms of action, therapeutic effects (e.g., antihypertensive, antidiabetic, galactagogue, hemostatic, antioxidant), and clinical relevance were critically evaluated.
Results: All ten plants demonstrated pharmacological potential relevant to perinatal health challenges. Notably, Zingiber officinale offers antiemetic and anti-inflammatory benefits during early pregnancy, complementing the lactogenic, antihypertensive, and wound-healing properties of other species. However, gaps persist in human trials, dosage standardization, and regulatory oversight.
Conclusion: The review highlights the importance of integrating validated traditional botanicals into perinatal care through interdisciplinary research, targeted clinical trials, and culturally responsive health policies. Bridging ethnopharmacology with maternal health systems offers a scalable, sustainable pathway toward maternal wellness and equity in Indonesia and comparable global settings.
Abstract 